tag:blogger.com,1999:blog-5472921328078253036.post1130964973224049888..comments2024-01-27T19:53:22.965-08:00Comments on Current Research into Cures for Type-1 Diabetes: Three Months Of New StudiesJoshua Levyhttp://www.blogger.com/profile/05300553471793001620noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-5472921328078253036.post-78346146312629436572019-02-09T07:48:21.325-08:002019-02-09T07:48:21.325-08:00Absolutely agree with all the facts. But anti il 2...Absolutely agree with all the facts. But anti il 21 is a new therapy, now tested in clinical trials, with low toxicity (if any) since it suppresses only one cytokine (il 21) mainly responsible for all autoimmune diseases, including diabetes T1. Also, Diamyd Medical is launching new vaccine next year. Stay positive! TETKA MILEVAhttps://www.blogger.com/profile/18264777046922751395noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-30622207270897000452019-02-08T13:12:46.074-08:002019-02-08T13:12:46.074-08:00GABA is a fairly interesting therapeutic strategy ...GABA is a fairly interesting therapeutic strategy for curing type 1 diabetes, since GABA not only promotes the conversion of pancreatic alpha cells to beta cells, but it also partially suppresses the autoimmune attack on the beta cells, and additionally offers some protection against the toxicity of certain immunosuppressive drugs, such as tacrolimus. The problem is that it does all of these things only to a limited degree, so difficulties would still remain. The most challenging aspect of using GABA to regrow beta cells, apart from its needing supplementation by toxic immunosuppressive drugs, is the fact that GABA can triple or quadruple levels of human growth hormone in the body, which very powerfully promotes diabetic complications, especially diabetic retinopathy. So would it be a net benefit to increase beta cell mass at the expense of life-long immunosuppression and its associated toxicity, plus a constant promotion of diabetic complications by human growth hormone? Probably not.Oscarhttps://www.blogger.com/profile/02915452402029137589noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-55137135385061001942019-02-06T13:09:07.849-08:002019-02-06T13:09:07.849-08:00What about Gaba + anti il 21? Have you considered ...What about Gaba + anti il 21? Have you considered this combination?TETKA MILEVAhttps://www.blogger.com/profile/18264777046922751395noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-92035469524948690932019-02-03T09:38:33.267-08:002019-02-03T09:38:33.267-08:00Thank you for taking the time to share this update...Thank you for taking the time to share this updated information. I look forward to looking more into some of these. Inflammation and diabetes has been extremely interesting to me as of late due to some of the things my late-ex dealt with and possibly had. http://burntapple.com/2019/02/02/18-and-the-teenager-who-rations-his-insulin-to-save-his-parents-money-prompts-this-memory-and-plea/Traci, BurntApple.comhttps://www.blogger.com/profile/13508933260838073256noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-77761010336793860942019-01-27T11:05:49.897-08:002019-01-27T11:05:49.897-08:00Of the three cure-oriented studies you cite, the f...Of the three cure-oriented studies you cite, the first, the MAS-1 adjuvenated insulin B-chain intervention, seems designed just to reduce the autoimmune aspect of diabetes, but since Faustman has long since shown that beta cells won't grow back just because the autoimmune attack on them is suspended, this study won't accomplish much without something to stimulate beta cell growth. Similarly, the second study, using AGO19 or AGO19 plus teplizumab to combat recent-onset type 1 diabetes in order to preserve as many beta cells as possible, would only help very new onset patients, as would an intervention with any other immunosuppressant or immuno-modulator, which have been tried since forever. Finally, the GABA study has probably already been performed but unknowingly, since GABA is a very popular supplement for mood elevation and pain relief, so among those using it there must have been many type 1 patients, yet no diabetes cures among them have been reported. But this is to be expected, since GABA only promotes the conversion of other cells to beta cells, which will only intensify the autoimmune attack by increasing the beta cell mass it targets, and probably just worsen the inflammation that type 1 diabetics already suffer, and this is causally implicated in the development of diabetic complications. GABA would have to be combined with some immunosuppressive intervention to show any benefit, performing the role of Faustman's INGAP polypeptide, and so the experiment probably won't show any results in the absence of immunosuppression. But given the unacceptable toxicity of immunosuppressives, increasing beta cell mass may not be part of a viable route to curing type 1 diabetes.Oscarhttps://www.blogger.com/profile/02915452402029137589noreply@blogger.com