tag:blogger.com,1999:blog-5472921328078253036.post1168385395548457105..comments2024-01-27T19:53:22.965-08:00Comments on Current Research into Cures for Type-1 Diabetes: Dr. Faustman's Phase-I ResultsJoshua Levyhttp://www.blogger.com/profile/05300553471793001620noreply@blogger.comBlogger21125tag:blogger.com,1999:blog-5472921328078253036.post-77697612665256018102013-09-23T21:43:31.649-07:002013-09-23T21:43:31.649-07:00Dear Josh,
My name is Dr. Abdul. I love your blog...Dear Josh,<br /><br />My name is Dr. Abdul. I love your blog and I am working on a platform that's unique in helping research progress. I would like to share this with you. Could you please email me your contact at<br /><br />aabdulwaheed@post.harvard.edu<br /><br />ThanksDRABDULhttps://www.blogger.com/profile/06184971380912714689noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-5094663783467044512013-09-23T21:43:28.920-07:002013-09-23T21:43:28.920-07:00Dear Josh,
My name is Dr. Abdul. I love your blog...Dear Josh,<br /><br />My name is Dr. Abdul. I love your blog and I am working on a platform that's unique in helping research progress. I would like to share this with you. Could you please email me your contact at<br /><br />aabdulwaheed@post.harvard.edu<br /><br />ThanksDRABDULhttps://www.blogger.com/profile/06184971380912714689noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-50961730812583032402013-09-23T21:43:25.189-07:002013-09-23T21:43:25.189-07:00Dear Josh,
My name is Dr. Abdul. I love your blog...Dear Josh,<br /><br />My name is Dr. Abdul. I love your blog and I am working on a platform that's unique in helping research progress. I would like to share this with you. Could you please email me your contact at<br /><br />aabdulwaheed@post.harvard.edu<br /><br />ThanksDRABDULhttps://www.blogger.com/profile/06184971380912714689noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-18328941699502368642013-09-23T21:43:23.666-07:002013-09-23T21:43:23.666-07:00This comment has been removed by a blog administrator.DRABDULhttps://www.blogger.com/profile/06184971380912714689noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-58899318994582019012013-09-23T21:42:24.373-07:002013-09-23T21:42:24.373-07:00Dear Josh,
My name is Dr. Abdul. I love your blog...Dear Josh,<br /><br />My name is Dr. Abdul. I love your blog and I am working on a platform that's unique in helping research progress. I would like to share this with you. Could you please email me your contact at<br /><br />aabdulwaheed@post.harvard.edu<br /><br />ThanksDRABDULhttps://www.blogger.com/profile/06184971380912714689noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-59016885918819623992012-04-09T21:40:14.626-07:002012-04-09T21:40:14.626-07:00Most scientists who have changed our world were no...Most scientists who have changed our world were not believed or validated until they persevered through to the end product. Would you have funded Steve Jobs in his garage oh so many years ago? I think Dr. Faustman should be funded and she should get on with phase 2 of human trials and we'll see what happens. Debating about whether she is right or wrong, altruistic or self serving, etc... is a waste of time. Most people who change the world have minds to which are difficult for the lay person to relate. We need these people and we need to believe in their research to see it through to the end. The cure that she believes in would bring in no money for all of the pharmaceutical companies invested in Type 1 Diabetes. It's big business. Big business has power and I am assuming she cannot reveal particular aspects of her study because she does not want them obliterated before they even make it to the testing phase. Sometimes, we just have to believe and support without knowing every single detail along the way.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-76215647973076865452012-03-05T06:42:07.737-08:002012-03-05T06:42:07.737-08:00Nothing new on the phase 1 study has been publishe...Nothing new on the phase 1 study has been published since last Summer. The last update I got (directly from Dr. Faustman herself), is that a paper had been submitted and was under consideration, and there was nothing to do but wait.<br /><br />Dr. Faustman did publish a paper just last week on very low levels of C-peptides found in long term diabetics. Although not testing BCG, this paper does provide background information that will help understand her BCG research, when it is eventually published.<br /><br />JoshuaJoshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-4991018603479575172012-03-03T11:35:12.704-08:002012-03-03T11:35:12.704-08:00Has the report on Dr. Faustman's Phase I study...Has the report on Dr. Faustman's Phase I study of BCG been published? I looked at clinicaltrials.org, where I thought results have to be published within 12 months of completion of a trial, but I didn't find her trial there. I had read that her trial completed in February of 2011, so now more than 12 months have passed since the completion of the trial.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-65499907084577328742011-10-09T11:08:41.573-07:002011-10-09T11:08:41.573-07:00I'd like to know how much of that $10 million ...I'd like to know how much of that $10 million was spent on developing machinery/technology for which Dr. Faustman will likely seek patents? She administered the vaccine to only 3 people?? Seriously??? Is this what folks who desperately seek the cure so generously donated their money for? I smell a rat (and I'm not talking about a lab rat either).Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-15351066773413192652011-09-28T23:48:24.821-07:002011-09-28T23:48:24.821-07:00There was a recent cancer success story - phase1 t...There was a recent cancer success story - phase1 trial with only 3 patients! did you see that?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-91999432901322712572011-09-01T20:04:55.202-07:002011-09-01T20:04:55.202-07:00Thanks Anonymous for posting that.. I posted a lon...Thanks Anonymous for posting that.. I posted a long winded comment but it somehow never showed up hereAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-4597541222465854972011-08-27T20:30:45.555-07:002011-08-27T20:30:45.555-07:00From the Faustman Lab Notes on Facebook :
http://...From the Faustman Lab Notes on Facebook :<br /><br />http://www.facebook.com/#!/notes/faustman-lab/thinking-about-trial-size/10150264344272572Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-76628039932672035242011-08-19T19:14:13.586-07:002011-08-19T19:14:13.586-07:00Here are some very quick and short thoughts on som...Here are some very quick and short thoughts on some of the comments here:<br /><br />"I do not believe for one second that MGH and Harvard will put their reputation at risk on this."<br /><br />Remember that neither MGH nor Harvard review findings prior to publication. Those are prestigious places, and the fact that Dr. Faustman is associated with them shows she is a major researcher, and should be taken very seriously. However, the association does not say that her results are correct. And certainly, in the past people from those institutions (and similar) have said she is wrong. They are not monoliths, with one opinion.<br /><br />"I think the $10M didn't obviously go toward the blood tests - but in buying/developing the technology, the machines that are able to do the measurements in a much more accurate manner than ever before..."<br /><br />Certainly that is what Dr. Faustman said years ago. I think it is still true, although much of the rest of the trial has changed. However, that brings up another question: if the phase-I trial is expensive because they bought a bunch of special equipment, then why is the phase-II study even more expensive? You would think the equipment would still be available for the next round....<br /><br />"I also do not believe for one second Lee Iacocca would have put 8.5 mln for Phase II if he did not have good answers on Phase I."<br /><br />I don't think he did. 8.5 Million is the total amount raised so far (approximately). I don't think the lab has said how much of it is from Mr. Iacocca.<br /><br />"There are plenty of small phase 1 studies out there, so I am not sure why that is such a big issue."<br /><br />This study was the absolute smallest study that I have ever heard of, aimed at curing type-1 diabetes and using an approved drug. I'm not saying it was small. I'm saying that it was vastly smaller than any other study. Five times smaller than most similar studies.<br /><br />Plus, there is the issue that it started out bigger, but was reported smaller. Not a good sign.<br /><br />Joshua LevyJoshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-10501057502836852802011-08-19T07:20:23.639-07:002011-08-19T07:20:23.639-07:00There are plenty of small phase 1 studies out ther...There are plenty of small phase 1 studies out there, so I am not sure why that is such a big issue. Isn't the point of phase 1 a small trial to get a sense of the drug? Plus wasn't this trial done with blessing of the FDA? I think this would mean they signed off on the the number of patients, etc. I just don't see the scandal or the charlatanism (as another poster stated) here. I want to see what comes next, and I'm hopeful something good will come out of all of this. Fingers crossed.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-23978584968207784132011-08-18T20:49:03.410-07:002011-08-18T20:49:03.410-07:00I think the $10M didn't obviously go toward th...I think the $10M didn't obviously go toward the blood tests - but in buying/developing the technology, the machines that are able to do the measurements in a much more accurate manner than ever before... there is something to this for sure, you know, the bad Tcells when killed, the pancreas regenerates. Now is it going to be BCG or some other medication... what is going to raise TNF levels sufficiently high to permanently turn off the bad Tcells.. All this can be studied with this new machine/mechanism/technology that the doctor has developed and tested, I think from all that I have gathered so far... Phase2 would definitely answer many questions...Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-41375331727090144582011-08-17T14:02:26.045-07:002011-08-17T14:02:26.045-07:00Original second poster here: I know that Faustman ...Original second poster here: I know that Faustman gets a lot of mileage from the Harvard thing, but listen, I went there. I did a PhD there. Faustman isn't paid by Harvard; she's paid out of her research grants (i.e. the people who donated to her). She has a Harvard affiliation because basically every doctor in Boston has a Harvard affiliation. It doesn't actually mean anything. <br /><br />I know less about the MGH thing, but again, it is probably just that Faustman has research money so Faustman can have a lab, which, again, is paid for by Faustman's research money.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-69273238198036981612011-08-15T01:34:49.469-07:002011-08-15T01:34:49.469-07:00It's hard to comment on these results, but i a...It's hard to comment on these results, but i agree with Papa Carlitos, that MGH and Harvard would not risk their reputation. If Faustman's work is of question, they would have fired her long ago.<br />Let's wait for the full paper.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-68374249449708623552011-08-12T23:10:40.042-07:002011-08-12T23:10:40.042-07:00My brain has a hard time with research. I'm i...My brain has a hard time with research. I'm interested in it...but sometimes it's hard for me to understand everything I'm reading.<br /><br />I really appreciate that you took the time to put this post together and offer an opinion based on your experiences with research.<br /><br />This site is a great resource for someone like me. THANK YOU!Anonymoushttps://www.blogger.com/profile/16704298016041843194noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-28788088169222626182011-08-12T20:57:58.753-07:002011-08-12T20:57:58.753-07:00Good analysis by Josh, but as he himself points ou...Good analysis by Josh, but as he himself points out, this is all based on the abstract and not the full paper. I do not believe for one second that MGH and Harvard will put their reputation at risk on this. I also do not believe for one second Lee Iacocca would have put 8.5 mln for Phase II if he did not have good answers on Phase I. So, let's be hopeful and wait for the paper!LarConBrihttps://www.blogger.com/profile/05673609391515865814noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-56936321298454982192011-08-11T02:06:49.540-07:002011-08-11T02:06:49.540-07:00This confirms the sense I got from her web site an...This confirms the sense I got from her web site and fundraising letters: She's a charlatan. <br />I'd love to be cured, but she's just making stuff up and paying herself a salary from the pockets of sick people and their families.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-31535487323737630422011-08-09T04:57:39.678-07:002011-08-09T04:57:39.678-07:00Thanks for the commentary, Josh. Where did the $10...Thanks for the commentary, Josh. Where did the $10M go? I am baffled over the study design... why did only 3 patients get the BCG? Hope these questions are answered shortly. I have serious concerns and now I'm wondering what JDRF knew years ago.Anonymousnoreply@blogger.com