tag:blogger.com,1999:blog-5472921328078253036.post2440603346749235449..comments2024-01-27T19:53:22.965-08:00Comments on Current Research into Cures for Type-1 Diabetes: Zhao et al (Tianhe) Publish Successful Phase-I Results (in non-honeymoon diabetics)Joshua Levyhttp://www.blogger.com/profile/05300553471793001620noreply@blogger.comBlogger15125tag:blogger.com,1999:blog-5472921328078253036.post-37797637097297943242012-06-06T08:42:40.942-07:002012-06-06T08:42:40.942-07:00In Asturias, Spain, in the Hospital Central de Ast...In Asturias, Spain, in the Hospital Central de Asturias (HUCA) Dr. Jesús Otero will start a trial after Summer with Zhao technique.<br /><br />More info (in spanish)<br />http://www.hayalternativas.org/noticias/?p=1015Anonymoushttps://www.blogger.com/profile/05126187721347445441noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-32922977876253937922012-01-21T12:18:56.947-08:002012-01-21T12:18:56.947-08:00Anonymous, I agree this should deserve breakthroug...Anonymous, I agree this should deserve breakthrough treatment in the news. If there's anything we can do as parent/patient community, I'm on!LarConBrihttps://www.blogger.com/profile/05673609391515865814noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-59271988259138879872012-01-19T11:25:59.320-08:002012-01-19T11:25:59.320-08:00I fear big pharma will buy out the researchers on ...I fear big pharma will buy out the researchers on this research since it is so promising. ALso, shouldn't this be big news. I consider this a hugh breakthrough. Why is it no where in the news, unless I missed it. It's not even on JDRF website???Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-11537259086594774792012-01-19T04:40:05.905-08:002012-01-19T04:40:05.905-08:00I am excited to see the increased C-peptides in th...I am excited to see the increased C-peptides in this study. That says that this intervention shows real promise. I hope to see results of the clinical trials soon.Kathyhttps://www.blogger.com/profile/03441855736336430014noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-15558698255559868012012-01-17T18:03:40.028-08:002012-01-17T18:03:40.028-08:00Hello Robert. I asked him specifically about othe...Hello Robert. I asked him specifically about other locations and he said it is only available in China at this time.LarConBrihttps://www.blogger.com/profile/05673609391515865814noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-12675186072303396632012-01-17T06:18:11.473-08:002012-01-17T06:18:11.473-08:00This is pretty exciting stuff. My wife is T1D and ...This is pretty exciting stuff. My wife is T1D and has been been since she was 10 1/2 months old. She has been pretty down about the prospects of a cure lately and I wanted to show her that progress is being made, it is just slow.<br /><br />To Papa C: Did the researcher indicate if they would be doing any trials here? I am not sure if she would be up for it, but I would like to suggest to my wife to get involved. No chance she would go to China to try something experimental though.<br /><br />ThanksRobert Bhttps://www.blogger.com/profile/01538429854801140526noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-18814431324841076072012-01-16T11:26:02.647-08:002012-01-16T11:26:02.647-08:00These results are encouraging because they suggest...These results are encouraging because they suggest that immune suppression alone can induce beta cell regeneration. But the stem cells likely educate Tregs with a wide variety of antigen-specificities, so it may be like systemic immunosuppression, which has side effects. Perhaps the approach could be used as inducer therapy and combined with something more antigen-specific to sustain the effect.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-26338286280323930662012-01-15T18:09:40.715-08:002012-01-15T18:09:40.715-08:00By the way, it is available. The researcher told ...By the way, it is available. The researcher told me we can participate in the trial without problems, in China.LarConBrihttps://www.blogger.com/profile/05673609391515865814noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-67183016992296370822012-01-15T17:12:00.714-08:002012-01-15T17:12:00.714-08:00Josh and all, I wrote to the researcher and got so...Josh and all, I wrote to the researcher and got some details. It seems indeed that he processes all of the body's blood. See below:<br /><br /><br />QUOTE<br />Question: is all of the blood from the body processed for lymphocyte separation or just one draw? <br /> <br />Answer: There is a holding needle in the patient’s arm for blood draw. Every time, the blood cell separator automatically draws a small amount of blood for isolation of lymphocytes, plasma and red blood cells are returned automatically to the patient blood circulation. This is continuing process for 10 cycles. <br /> <br />Question: was there further improvement in the A group after 12/24 weeks? would you suggest, i.e. to do a second round to target full remission? <br /> <br />Answer: That is the goal in our next trial. We will try additional treatment to improve the therapeutic potential.<br /> <br />Question: is this supposed to be permanent or will patients need to be treated on a frequent basis? sorry again if this is a silly question from a non scientist!<br /> <br />Answer: Based on our research data, cord blood stem cells can radically modulate and correct the autoimmune cells. You know that T1D is very complicated with different causes, including environmental factors, food, life style, and etc. These potential factors may affect the effectiveness after treatment with Educator therapy. Additional treatments may be necessary to strengthen the effectiveness.LarConBrihttps://www.blogger.com/profile/05673609391515865814noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-59472548964343603872012-01-15T05:32:35.241-08:002012-01-15T05:32:35.241-08:00pdx_dc: I don't have an opinion about why it w...pdx_dc: I don't have an opinion about why it works, or exactly how it works. I cover research "from the outside" meaning that I look at the results. These results are good. As to what is happening on the inside? That is for someone else to discuss. Someone with a lot more knowledge of the immune system, than I have.<br /><br />As for funding: JDRF already funded this phase-1 trial, so I assume there will not be any problems having them fund follow on work.Joshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-89375388237957211792012-01-15T05:22:01.671-08:002012-01-15T05:22:01.671-08:00Papa C: I agree with your comments, and I don'...Papa C: I agree with your comments, and I don't really know if they put some blood through or all of it. I don't think this is going to be available really soon in any case.Joshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-45120552534462790722012-01-14T10:23:10.998-08:002012-01-14T10:23:10.998-08:00Thanks so much for your blog. Saves hours of rese...Thanks so much for your blog. Saves hours of research on my part, and I must confess I wouldn't even know where to begin. An A1c of 12 may not be at all rare in Third World Countries; and Type 1s are in dire need of a cure in places where they do not always have access to insulin, let alone the newer analogs. I can see why it might be easier to get volunteers for clinical trials. Our DD was cured in vitro in a study done at Naomie Berrie Diabetes Center recently; and I don't believe they have conducted Phase 1 trials. Of the nine patients tested, 7 were cured in vitro. Granted the cure only worked in the petri dish but if it works in vivo this would be a simple, safe cure for a high percentage of Type 1s (not all). I believe more studies may be out there with promising results. I have hope, but I also think with the complexity of the autoimmune process, the cure is decades away. Perhaps the cure will come sooner than planned,from an accidental discovery. It's happened before.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-34199652818548188932012-01-14T08:29:37.811-08:002012-01-14T08:29:37.811-08:00I read paper this and am left with far more questi...I read paper this and am left with far more questions than I am comfortable with. <br /><br />In part due to other news this week identified CD8 T cells as the source of the autoimmune response that causes type 1.*1 There is a quote from ViaCyte on Diabetes Mine that spoke to the difficulty of getting stem cells to differentiate into beta cells.*2 For that I presume that getting a stem cell to differentiate into any specific cell is an involved proposition. <br /><br />The lymphocytes reprogramed here are already differentiated cells. If the autoimmune process is stopped it is due to a modification or reeducation of these CD8 T cells. There are a myriad of CD8 cells and they are created in the lymph nodes to recognize specific antigens on the cells the are programmed to kill. <br /><br />So we are to believe that exposure to stem cells changes the antigen receptors? If that is true then why don’t the processor stem cell to the lymphocytes in our bone marrow have the same effect. I also fail to see a mechanism to explain how this erase the memory of the adaptive immune system. <br /><br />All that said I would love to see a cure. I get excited by headlines just like everyone else. I hope this is repeatable. I have come to be suspicious of reports of apparatus that seem to good to be true. <br /><br />1 La Jolla Institute researchers identify pivotal immune cell in Type 1 diabetes in humans, http://www.eurekalert.org/pub_releases/2012-01/ljif-lji011112.php<br /><br />2 http://www.diabetesmine.com/2012/01/whats-up-with-diabetes-stem-cell-research-firm-viacyte.htmlBennethttps://www.blogger.com/profile/17411395744352827620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-10363217007933757612012-01-13T19:32:31.662-08:002012-01-13T19:32:31.662-08:00Thanks Joshua! I am glad you reviewed this quickly...Thanks Joshua! I am glad you reviewed this quickly! was holding my breath :-) <br /><br />This clearly proves "regeneration" concept. Also umblical cord blood should be available easily without controversies. <br /><br />I have a doubt about whether these cord stem cells simply clean up the bad T-cells - or - whether they fix the bone-marrow to stop making the bad T-cells in the first place...<br /><br />I am thinking its the latter.. do you agree? is that why they call it "education"? Hurry up with Phase-11 please!!!! Also the A1C dropping substantially in 3 months is BIG PROOF that regeneration has taken place and susbtantial C-peptide has been generated and substantial Insulin has been generated....isn't that awesome? (even if I can't still personally understand or appreciate the actual C-peptide figures) JDRF will fund this? wouldn't that be nice to see accelerated results..PaviTravelStorieshttps://www.blogger.com/profile/08676668177724253687noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-56113231198731237412012-01-12T19:10:26.112-08:002012-01-12T19:10:26.112-08:00Thanks Josh, I was very excited when the news brok...Thanks Josh, I was very excited when the news broke a couple of days ago and was really looking forward to reading your comments on this. <br /><br />I agree it is big, if this education happens merely by exposing rogue T-cells to a third party stem cell it would be huge news not only for Type 1 Diabetes but for medicine in general. Other than the significance of the breakthrough, the most exciting part is that it is a very concrete thing, and apparently readily available.<br /><br />By reading the paper in its entirety, I'm not sure if this is just a draw of blood or that all of the blood is processed to extract all of the body's lymphocytes and then expose them through the "educator" for re-insertion into the patient's body. <br /><br />QUOTE<br />A 16-gauge IV needle was placed in the left (or right) median cubital vein, and the patient’s blood was passed through a Blood Cell Separator MCS+ (Haemonetics®, Braintree, MA, US) at 35 mL/min for 6 to 7 hours to isolate lymphocytes in accordance with the manufacturer’s recommended protocol. The collected lymphocytes were transferred into the device for exposure to allogeneic CB-SCs (or process control without CB-SCs), and other blood components were returned to the patient. After 2 to 3 hours in the device, lymphocytes were returned to the patient’s circulation via a dorsal<br />vein in the hand under gravity flow control (2 to 3 mL/min) with physiological saline. Approximately 10,000 mL of blood was processed during the procedure resulting in approximately two repeated educations for the lymphocyte fraction. Patients were hospitalized for two days to monitor temperature and conduct routine laboratory blood tests for adverse reactions following treatment. <br />UNQUOTE<br /><br />On the Phase II versus "surgical procedure exemption", it is a very relevant issue as it may be the difference between having this available "today" versus several years for Phase II/III/Marketing. If we take the Regenerative Sciences case as a precedent (not identical, but conceptually applicable), the FDA may go the conservative route and demand full phase II/III cycle. made it abundantly clear that any processing of internal body material will be considered to be a drug.<br /><br />Definitely to be continued...LarConBrihttps://www.blogger.com/profile/05673609391515865814noreply@blogger.com