tag:blogger.com,1999:blog-5472921328078253036.post2961945468001267800..comments2024-01-27T19:53:22.965-08:00Comments on Current Research into Cures for Type-1 Diabetes: Vitamin D and Omega-3s (EPA/DHA "Fish Oil") Start a Patient Driven StudyJoshua Levyhttp://www.blogger.com/profile/05300553471793001620noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-5472921328078253036.post-59248450934529234912018-12-06T08:53:57.687-08:002018-12-06T08:53:57.687-08:00You could argue the possibility that the people li...You could argue the possibility that the people likely to enroll themselves or their dependents in the internet trial, may not be the same population that feel comfortable actually going the strict clinical route. Thus the confounding factors of subjects trialing multiple therapies simultaneously or draining participants one to the other may not be as big a deal as you envision.Reverse Developerhttps://www.blogger.com/profile/13365731358544634396noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-30723294325252537092018-12-03T13:53:47.750-08:002018-12-03T13:53:47.750-08:00Conventional medicine, in which everything from me...Conventional medicine, in which everything from medical journal costs to student funding to advertising and lobbying, as well as directing government regulations through the 'revolving door' phenomenon is controlled by 'Big Pharma,' does not even want to contemplate the possibility that non-patentable substances might be medically effective, so it is no coincidence that this research is being done by a grassroots organization. Still, even conventional medicine has looked at this option in published studies; for example, see:<br /><br />"Diabet Med. 2013 Feb;30(2):161-9.<br />Primary and secondary prevention of Type 1 diabetes.<br />Skyler JS<br /><br />Since type 1 diabetes is an immunologically mediated disease, immune intervention should alter the natural history of the disease. This article reviews prevention studies undertaken either prior to any evidence of autoimmunity (primary prevention) or after the development of islet autoantibodies (secondary prevention). Most immune intervention studies have been conducted in recent-onset type 1 diabetes (tertiary prevention), and these are not reviewed herein. The goal of primary and secondary intervention is to arrest the immune process and thus prevent or delay clinical disease. Primary prevention studies have been conducted in infants with high genetic risk. Interventions tested include several dietary manipulations, including infant formulas free of either cow's milk or of bovine insulin, infant formula supplemented with the omega-3-fatty acid docosahexaenoic acid, delayed introduction of gluten-containing foods, and vitamin D supplementation. Secondary prevention studies have been conducted in both children and adults with diabetes autoantibodies. Interventions tested include nicotinamide, insulin injections, oral insulin, nasal insulin, glutamic acid decarboxylase, and cyclosporine. Underway are secondary prevention studies with teplizumab and with abatacept."<br /><br />There are also many studies showing that anti-inflammatory natural substances, such as astaxanthin, can be beneficial in interrupting the inflammatory mechanism by which hyperglycemia actually causes its damage, and the good thing about breaking the hyperglycemia-diabetic complications chain at the inflammatory process link is that there is no hypoglycemia risk in this intervention as there is in strict control with insulin. So substances such as are being studied to prevent the onset of type 1 diabetes may also be useful to delay, diminish, or prevent the complications of established diabetes.<br />Oscarhttps://www.blogger.com/profile/02915452402029137589noreply@blogger.com