tag:blogger.com,1999:blog-5472921328078253036.post4397397089936515750..comments2024-01-27T19:53:22.965-08:00Comments on Current Research into Cures for Type-1 Diabetes: Results From Phase-I Clinical Trial of Proinsulin Peptide Vaccine in Honeymooners (MonoPepT1De)Joshua Levyhttp://www.blogger.com/profile/05300553471793001620noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-5472921328078253036.post-74946192288258556892017-11-15T07:59:08.693-08:002017-11-15T07:59:08.693-08:00Well, the cells for transplant would either have t...Well, the cells for transplant would either have to have been preserved from the patient before the patient's beta cells were destroyed, or they would have to have been made from the pluripotent stem cells of the patient, which is not an easy task. If you take them from any other source, then even if you have found a way to stop the patient's own autoimmunity from acting, you are going to have to put the patient on toxic life-long immunosuppression to combat the ordinary immune processes of the body. <br /><br />There is also the problem of the extreme shortage of pancreases for transplant even now, with the very limited number of pancreas transplants which are performed. Transplanting beta cells from animal sources, which could be done if they could be encased in capsules protecting them from the immune system, would solve the shortage of material to transplant, but it could not work without encapsulation, given the hyperacute rejection which results from transplanting animal tissue into humans.Oscarhttps://www.blogger.com/profile/02915452402029137589noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-58742616576149446272017-11-14T23:39:59.269-08:002017-11-14T23:39:59.269-08:00Oscar, I have to disagree with you. The success of...Oscar, I have to disagree with you. The success of a "prevention"-type cure would open the door to a cure for all who are currently living with type 1. If the progression of type 1 autoimmunity can be stopped, transplanted islet cells from donor cells or from the lab would potentially become a long-term cure. We might see the widespread success of an Edmonton-protocol transplant cure, without the immunosupression and without the degradation of transplanted islet cells insulin production.Anonymoushttps://www.blogger.com/profile/12602372527058285908noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-67977524662416462262017-11-07T18:31:37.625-08:002017-11-07T18:31:37.625-08:00I agree with OscarI agree with Oscarcelinhogomes1https://www.blogger.com/profile/08812529312371153515noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-6034013956039176112017-11-05T19:56:18.094-08:002017-11-05T19:56:18.094-08:00The danger with this, as with all efforts to preve...The danger with this, as with all efforts to prevent type 1 diabetes from developing or to stop its evolution in the initial phase, is that it will make those who now have an established case of the disease the 'last generation of freaks,' mere medical curiosities who will be pitied but whose condition will no longer attract any scientific research efforts since once we are gone, the disease shall have vanished, like the English Sweating Disease and similar conditions of the past. So, ironically, progress in such efforts is the last thing that should encourage us.Oscarhttps://www.blogger.com/profile/02915452402029137589noreply@blogger.com