tag:blogger.com,1999:blog-5472921328078253036.post4438355408176987718..comments2024-01-27T19:53:22.965-08:00Comments on Current Research into Cures for Type-1 Diabetes: Possible Cures for Type-1 in the News (January)Joshua Levyhttp://www.blogger.com/profile/05300553471793001620noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-5472921328078253036.post-66820298222903444132017-01-30T10:32:22.544-08:002017-01-30T10:32:22.544-08:00This comment has been removed by a blog administrator.Brunohttps://www.blogger.com/profile/17105149257424826726noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-71443745641630811822017-01-28T14:33:38.785-08:002017-01-28T14:33:38.785-08:00The comment just above this (by Bruno) contained a...The comment just above this (by Bruno) contained a personal story about someone who got a vaccination, and then later came down with type-1 diabetes (with no history of type-1 in the family). I deleted it.<br /><br />Please remember: almost everyone gets vaccines. Therefore almost everyone who is diagnosed with type-1 diabetes has been vaccinated. And since almost everyone who is diagnosed with type-1 has been vaccinated, some of them will be recently vaccinated, just by chance. Also, remember that most people diagnosed with type-1 diabetes do not have a known history of type-1 in their families. But these same families often do have a history of other autoimmune diseases (with related genetics). Also, unless you know exactly how all your grandparent's (and great-grandparent's) siblings died, then you don't really know about type-1 in your family.<br /><br />The important thing is that many studies have been done on vaccines and type-1 specifically, and they have never found that people who are vaccinated are at higher risk overall. I've blogged about this before:<br />http://cureresearch4type1diabetes.blogspot.com/2015/02/hpv-vaccination-and-type-1-diabetes.html (for HPV vaccines specfically)<br />http://cureresearch4type1diabetes.blogspot.com/2015/10/seasonal-flu-vaccine-and-type-1-diabetes.html (flu vaccines specifically)<br /><br />I have a draft for childhood vaccines, but it's not finished. I guess I should put some work into finishing it.<br /><br />Joshua<br /><br />Joshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-71146302766969814802017-01-27T07:39:28.312-08:002017-01-27T07:39:28.312-08:00This comment has been removed by a blog administrator.Brunohttps://www.blogger.com/profile/17105149257424826726noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-69185706537131897822017-01-26T18:29:31.193-08:002017-01-26T18:29:31.193-08:00I personally will be excited if a preventative int...I personally will be excited if a preventative intervention is found. For me, I would much rather a prevention be found than a cure is found for my diabetes. After 42 years. It is all about the grandchildren and their children. Rick Phillipshttps://www.blogger.com/profile/06927227605885917738noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-52555767395641259322017-01-26T14:00:17.740-08:002017-01-26T14:00:17.740-08:00Any interventions which either prevent or stop typ...Any interventions which either prevent or stop type 1 diabetes in its initial development will leave the millions of people who already have an established case of the disease stranded, since the motivation of governments, the general public, charities, large donors, researchers, and financially motivated pharmaceutical companies to find a genuine cure will be greatly diminished. This is why I am less than enthusiastic about intranasal insulin, Diamyd, or a novel polio vaccine, which only aspire to prevent or just stop type 1 diabetes in its early phase. <br /><br />I am also cautious about any lines of treatment which involve manipulations of the immune system, as Il-2 and Diamyd do, since immunity is one of the most complicated and poorly understood aspects of human physiology. This means that the possibility of dangerous side-effects, which may well only become evident over decades, makes these approaches very risky. <br /><br />Simply stopping the autoimmune attack on beta cells, such as IL-2 and Diamyd attempt to do, seems unlikely to achieve very much, since all the evidence so far shows that damaged beta cells are difficult to coax back into operation even if the autoimmune assault is suspended. This is why Dr. Faustman, for example, has been trying to find some additional element to induce beta cells to recover function after the immunological attack has been blocked. It is interesting to note in this context that of all the countless type 1 diabetics who have endured sizeable and persisting immunosuppression, often for many decades, to tolerate a transplanted organ, not a single one has ever had any restoration of beta cell function.<br /><br />The tolerogenic approach attempted with intranasal insulin would be faced with the experimental difficulty that it is difficult to know what population is really at risk for type 1 diabetes, since while the disease is in part genetically conditioned, other factors are also involved, such that occasionally identical twins are seen in which one is a type 1 diabetic and the other is not. By the time immunological alterations are measurable, it may well be too late to achieve anything much. Also, there is considerable evidence that what induces the immunological attack on beta cells is not any problem with the immune system itself, but instead the deformed development of the beta cells, which causes the body to identify them as foreign tissue and attack them, even with a perfectly normal immunity.<br /><br />In short, the physiologically sophisticated approaches to curing type 1 diabetes all suffer either from having a great danger of side-effects, not being able to revive the beta cells even if the autoimmune attack is stopped, or taking many, many decades to be refined into a clinically applicable treatment. That is why I prefer a concerted effort to perfect a simple, mechanical solution like ensuring a sufficient oxygen supply for encapsulated islet cells. celsushttps://www.blogger.com/profile/16866111125834052493noreply@blogger.com