tag:blogger.com,1999:blog-5472921328078253036.post8056193404180689397..comments2024-01-27T19:53:22.965-08:00Comments on Current Research into Cures for Type-1 Diabetes: Background for the Artifical PancreasJoshua Levyhttp://www.blogger.com/profile/05300553471793001620noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-5472921328078253036.post-24731109203256044752009-11-25T00:50:23.403-08:002009-11-25T00:50:23.403-08:00Pancreas is one regarding which there is a varied ...Pancreas is one regarding which there is a varied understanding in today's day. There are many discoveries around the pancreas.. I made these <a href="http://www.funnelbrain.com/c-58296-.html" rel="dofollow" rel="nofollow"> flashcards</a> to ensure that everyone can understand the many details about this organ.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-11432631151550557932009-09-24T20:21:43.353-07:002009-09-24T20:21:43.353-07:00You bring up a good point about implanted vs. not ...You bring up a good point about implanted vs. not implanted, which I did not put in the posting: the difference between insulin put in blood and insulin put in fat.<br /><br />I'm confidant of our current pump and insulin technology, because I feel that it is already used to keep people in range for a day here and a day there, so I know it is possible.<br /><br />However, the real proof is in the clinical trials: if they work with current pumps and insulin, then the current pumps and insulin are good enough, and if not, then not. And it really doesn't matter what I think.Joshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-13257994557656593752009-09-12T20:00:02.658-07:002009-09-12T20:00:02.658-07:00I find it somewhat curious that you mention an imp...I find it somewhat curious that you mention an implanted artificial pancreas (IAP) vs. external pump, in part, because REGULAR insulin delivered directly into the bloodstream has a time-activity profile which is measured in minutes vs. hours for subcutaneously delivered analogues of any type -- that explains why only Regular insulin is used in IV drips in a surgical or hospital setting. Further, it does not have a long "tail" of activity which is common even with rapid-acting analogues. It seems to me that the whole point of an IAP is to address the problems with subcutaneous delivery, so the main challenge now is a) insulin concentration that is higher than U-500 and b) whether that insulin will last long enough inside the human body but not in the bloodstream, as the body temperature might be too high for any highly-concentrated insulin formulation to last for much more than a few months (and adding insulin via surgical procedure every few months is anything but practical).<br /><br />It is also unclear whether current pump technology, specifically with the threading on the pistons which deliver insulin today in dosages that are in fact, small enough.<br /><br />The current CGM technology is evidently not sufficient, but I think the categorization as having sufficient insulin and pump technology raises questions which have not been adequately addressed by technology presently on the market.Scott Shttps://www.blogger.com/profile/03286529314567223617noreply@blogger.com