tag:blogger.com,1999:blog-5472921328078253036.post8471225679583963895..comments2024-01-27T19:53:22.965-08:00Comments on Current Research into Cures for Type-1 Diabetes: Faustman's Research (Part 1: History)Joshua Levyhttp://www.blogger.com/profile/05300553471793001620noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-5472921328078253036.post-64180952162047163282010-12-17T16:33:53.208-08:002010-12-17T16:33:53.208-08:00To all Dr faustman supporters , you could help spe...To all Dr faustman supporters , you could help speed up the funding of Dr. Faustman's most promising research:<br /><br />A) to reverse type 1 diabetes <br />B) at cheap price (generic BCG)<br />c) with the safest approach (long history of safety use)<br /><br />How: You can join the lobby group newsletter totally free at http://www.hdiabetes.com <br />It's free to join. We will be stronger in group.<br /><br />Spread the word about the lobby group. We will fund the research fast.<br /><br />Thank youAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-9216106527594608562008-11-15T10:57:00.000-08:002008-11-15T10:57:00.000-08:00For kumquat79's second comment: please, do my rese...For kumquat79's second comment: please, do my research! Finding all the references in this post take a lot of time, and I'm always looking for good references.<BR/><BR/>I agree that there should be some general links to Faustman's work, and I'll add them to the next version of the blog entry.Joshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-56864119948263835272008-11-15T10:54:00.000-08:002008-11-15T10:54:00.000-08:00Mistake in my previous comment. The two Faustman ...Mistake in my previous comment. The two Faustman single dose experiments are not her most recent. They are just two of her experiments.Joshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-33338894323624199742008-11-15T10:52:00.000-08:002008-11-15T10:52:00.000-08:00For kumquat79's second comment, it is true that no...For kumquat79's second comment, it is true that none of these experiments are identical. Each uses slightly different doses, given at different ages. Faustman's current clinical trial involves giving two doses of BCG [r15], but this is not so different from the five clinical trials I site [r20,r21,r22,r23,r24] which used one dose.<BR/><BR/>However, if Faustman claims that more than one adjuvant dose is required to cure diabetes (as you say), then she is inconsistent with herself. Both of her most recent mice experiments used a single dose of adjuvant [r2,r25].<BR/><BR/>It seems more likely that faced with previous failures of clinical trials of BCG that used one dose, she decided to use two doses, in spite of the fact that her own previous mice experiments used one dose. The only hope for success is that CFA needs one dose and BCG needs two. Evidence that this is unlikely is the total ineffectiveness of one does of BCG. (If two doses did a full cure, you might expect one dose to have some effect, even if not a total cure.)<BR/><BR/>In my blog entry, I referred to four BCG human trials, but there are actually references to five. The extra one is [r24]Joshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-20137423450249936452008-11-15T10:32:00.000-08:002008-11-15T10:32:00.000-08:00For kumquat79's first post, as far as I know, the ...For kumquat79's first post, as far as I know, the proposals that Faustman submitted in 2001-2003 to JDRF and JLN have never been made public, so we can't see the actual document. However, there are several news articles that say specifically that she asked for funding to replicate her mice experiments. ("Replicate" would imply the same spleen cells.) I'll put in some references to this in an update that I'm panning next week.<BR/><BR/>There is also a common sense argument. Why would she experiment with adjuvants+spleen cells on mice, and then switch to just adjuvants on people? If she wanted to do adjuvants only in people, she would have started with adjuvants only in NOD mice.<BR/><BR/>Remember that Faustman had a change of focus of her research. In the 2001-2003 time frame it was adjuvant+spleen cells, but later on (certainly after 2006) she focused on adjuvant only research, and her interviews and public statements reflect that. <BR/><BR/>If you have any specific references to Faustman asking JDRF for money for a BCG only clinical trial in the 2001-2003 time frame, please tell me about them!Joshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-84970254910923391582008-11-14T14:55:00.000-08:002008-11-14T14:55:00.000-08:00Not trying to do your research for you, but here i...Not trying to do your research for you, but here is a link to her PNAS article from August, 2008:<BR/><BR/>http://www.faustmanlab.org/Publications/PNAS2008.pdf<BR/><BR/>And I thought I'd go ahead and throw out a couple more links for information:<BR/><BR/>www.faustmanlab.org<BR/><BR/>http://www.massgeneral.org/diabetes/laboratory_type1.htmkumquat79https://www.blogger.com/profile/18352224689826305492noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-30988122501506848042008-11-14T09:02:00.000-08:002008-11-14T09:02:00.000-08:00Also:"It's that I have the same level of excitemen...Also:<BR/><BR/>"It's that I have the same level of excitement for her work, as for any other research which is... (b) is testing a treatment which has previously failed -- in four previous experiments [r20,r21,r22,r23] -- when tested on people."<BR/><BR/>Those studies cited are not identical to the treatment Dr. Faustman is working on. Those were one-time vaccinations - Dr. Faustman has said repeatedly that that will not work.kumquat79https://www.blogger.com/profile/18352224689826305492noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-20707445195981328982008-11-14T08:48:00.000-08:002008-11-14T08:48:00.000-08:00Can you provide evidence for this:"The obvious nex...Can you provide evidence for this:<BR/><BR/>"The obvious next step was to run this CFA+spleen cell experiment in people. Faustman asked for research funding from the JDRF (Juvenile Diabetes Research Foundation) for exactly that human trial."<BR/><BR/>I have never heard that she wanted to try BCG <I>and</I> spleen cells in humans.kumquat79https://www.blogger.com/profile/18352224689826305492noreply@blogger.com