tag:blogger.com,1999:blog-5472921328078253036.comments2024-01-27T19:53:22.965-08:00Current Research into Cures for Type-1 DiabetesJoshua Levyhttp://www.blogger.com/profile/05300553471793001620noreply@blogger.comBlogger795125tag:blogger.com,1999:blog-5472921328078253036.post-45550333639217432302020-12-15T14:19:14.806-08:002020-12-15T14:19:14.806-08:00I consider it a real-enough facsimile of a cure, e...I consider it a real-enough facsimile of a cure, even if it's not sensitive enough to maintain glucose homeostasis after eating a whole pizza or chocolate cake in the phase 1 response. All the user would then need to do to maintain a decent TIR (time in range) is simply to cut carbs or spread them out throughout the day, and exercise enough to boost insulin sensitivity on the other end until the two curves meet, if you get my meaning.<br /><br />It's also clear that that superior TIR also helps nascent beta cells (even in type 1 diabetes) survive longer, giving them a better chance to mature to become glucose-detecting and glucose-mediated insulin secretors. This is a continuous process, and I think having fantastic blood sugars throughout the day (and especially at night) is going to have all kinds of other side benefits, like reducing long-term complications, stabilizing mood and irritability, and so on.<br /><br />I just know that many people are going to take massive amounts of this insulin and try to behave as if they aren't diabetic, then inevitably build up insulin resistance (and many type 1s get eventually, as they get older), which will lead them to have type 2 diabetes. Ultimately this drug does little to help prevent type 2 diabetes, because the problem there is too much insulin in the body, not a lack of it. But I frankly don't feel sorry for people who stuff their faces and expect drugs to keep them healthy. It doesn't work that way. <br /><br />The other benefit to this insulin that I predict, would be a drastic reduction in hypos. Which alone would be worth the price of admission. But combined with only taking a single shot per day, and not worrying about it, is worth it. Even if you have to take it easy on the carbs. Which, frankly, even non-diabetics should be doing anyway (lest they become type 2s, as so many eventually do).RLBURNSIDEhttps://www.blogger.com/profile/04757549198262931246noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-25945557084478147182020-08-29T11:22:09.291-07:002020-08-29T11:22:09.291-07:00Wonderful work, thank you so much!
Scotty K=Millay...Wonderful work, thank you so much!<br />Scotty K=Millay KingScottyhttps://www.blogger.com/profile/16389416765802477009noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-64216009236626101112020-08-26T07:46:33.488-07:002020-08-26T07:46:33.488-07:00Any news on this >3 years later?Any news on this >3 years later?MDhttps://www.blogger.com/profile/13335145356200939375noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-83028106323074633612020-08-17T13:54:17.140-07:002020-08-17T13:54:17.140-07:00Revolitionary curable treatment of diabetes witch ...Revolitionary curable treatment of diabetes witch eliminates completly hipo and hiperglycaemia in clinical trials in a few days or weeks.<br /><br />"Additionally, the CSO explains that Novo Nordisk hopes to commence phase 1 trials with yet another insulin in this half-year, if all goes according to plan.<br />In this case, Novo Nordisk is looking at a "glucose-responsive insulin," which means that the insulin only works when a patient's blood sugar levels are too high and goes into standby when the blood sugars are too low.<br />If it works as intended, diabetics no longer have to worry about hypoglycemia when they take insulin. It also means that they do not have to measure their blood sugar levels quite as often.<br />"It's something everyone has been looking for for decades, and it seems we may have cracked the code. We are pretty excited to see how it turns out in humans," says Krogsgaard Thomsen."<br /><br />https://m.medwatch.dk/article/12276999Anonymoushttps://www.blogger.com/profile/15757516946549434505noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-20204743960751411062020-07-23T14:33:54.340-07:002020-07-23T14:33:54.340-07:00Have you seen this?It is really interesting. They ...Have you seen this?It is really interesting. They make almost the same like Viacyte and Semma but with very little money. That fact is also hopefully.<br /><br /> https://www.theguardian.com/society/2020/jul/23/israeli-firm-says-micro-pancreas-to-cure-diabetes-ready-for-uk-trialsCoconuthttps://www.blogger.com/profile/18153852770076414333noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-46206911658832867862020-06-09T22:35:25.650-07:002020-06-09T22:35:25.650-07:00Jon, do you mean GABA levels? If so, they did not...Jon, do you mean GABA levels? If so, they did not report on them in their paper, so I don't know anything about them. --JoshuaJoshua Levyhttps://www.blogger.com/profile/05300553471793001620noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-30040819963975758622020-06-08T21:10:36.788-07:002020-06-08T21:10:36.788-07:00It's always good to be skeptical but this is e...It's always good to be skeptical but this is exciting stuff. I like how you've been mildly nudging for more ad hoc, off label script testing for this, given the safety record of fenofibrates.<br /><br />I think a lot of type 1s on fenofibrates haven't been on other beta cell regen drugs like GLP-1 at the same time. We know from other recent studies that GLP-1 + harmine HCL regenerates beta cells in vitro by 6%, so the big question here is, will fenofibrate + beta cell regen help reverse established type 1. Probably not, but worth a try. If other honeymooning type 1s can at least stay off the scag if they get on fenofibrates right away, then that opens up the notion that this drug, and this drug alone, can at least protect against antibodies killing off remaining beta cells (or keep killing off immature beta cells, because as we know, pancreases are constantly trying to create new ones, they just keep getting killed off faster than they can grow, let alone mature into glucose-mediated insulin-producing factories).<br /><br />Hopefully you'll be able to retire this blog soon, and all us type 1s can go on to live normal lives. Or as normal as can be, given the circumstances. I'd take any respite from this disease. I personally think GLP-1 meds plus harmine + fenofibrate + temporary immune suppression + maybe cyclical fasting can help established type 1 reverse course. Even if meds are still necessary, at least insulin won't be, and that's the hardest drug to take because of its side effects. GLP-1 might make you throw up for a day when first trying it, and metformin give you the runs, but insulin OD is a constant threat. Reactions are only one mistake away. I'd happily replace the needle with any number of pills or 1/week shots as necessary until a final gene therapy cure is ready.RLBURNSIDEhttps://www.blogger.com/profile/04757549198262931246noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-40776494883077725752020-06-06T16:38:38.425-07:002020-06-06T16:38:38.425-07:00This is fascinating. Thanks for sharing. Do we kno...This is fascinating. Thanks for sharing. Do we know if this patient's GADA levels normalized as a result of this therapy? Jonhttps://www.blogger.com/profile/07623614052620183865noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-66201388036619695882020-06-04T08:32:06.392-07:002020-06-04T08:32:06.392-07:00Hi Joshua,
I just want to thank you for these thor...Hi Joshua,<br />I just want to thank you for these thorough reviews of the latest T1D research and information, and for your continued advocacy for a T1 cure. This blog is a valuable resource and is very much appreciated.Jim Ohttps://www.blogger.com/profile/12562279671742344270noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-22401528873511947702020-03-03T18:31:13.252-08:002020-03-03T18:31:13.252-08:00Hi Joshua, here please find the website for Avotre...Hi Joshua, here please find the website for Avotres.<br />https://www.avotres.com/Anonymoushttps://www.blogger.com/profile/00416126987081068504noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-57861954909431792872019-12-17T05:34:18.467-08:002019-12-17T05:34:18.467-08:00Did this ever happen? I cannot find any new info ...Did this ever happen? I cannot find any new info on it Dec 2019 right nowAnonymoushttps://www.blogger.com/profile/10878016003902747752noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-89494107312930161312019-11-23T19:43:25.301-08:002019-11-23T19:43:25.301-08:00That is interesting I use Rituxan to suppress RA a...That is interesting I use Rituxan to suppress RA and AS. I believe in this case if i understand correctly is that the attempt is to enhance or promote IL10 where as Rituxan is designed to suppress IL10. It seems odd. Rick Phillipshttps://www.blogger.com/profile/06927227605885917738noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-19284789356098956212019-11-19T00:19:12.664-08:002019-11-19T00:19:12.664-08:00This will be a lot harder with what is being passe...This will be a lot harder with what is being passed off as food these days. GMO's and Bio-engineered ingredients is and has caused problems for our gut microbiota. I believe you are correct in thinking that we should study this. Thanks for sharing the results your research with us. <br /><br /><br /><br />Anonymoushttps://www.blogger.com/profile/17460052651969609583noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-18403837433875408432019-11-17T10:50:02.349-08:002019-11-17T10:50:02.349-08:00Thanks. This is a useful analysis. Thanks. This is a useful analysis. Jeremyhttps://www.blogger.com/profile/02261085699933835576noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-62976743424092828042019-10-29T16:35:41.333-07:002019-10-29T16:35:41.333-07:00The immune system is attacking beta cells, not ins...The immune system is attacking beta cells, not insulin.TrevorMLhttps://www.blogger.com/profile/18066857498499368327noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-68146970124237822922019-10-19T18:16:01.377-07:002019-10-19T18:16:01.377-07:00I am afraid i do not hold out much hope here, give...I am afraid i do not hold out much hope here, given that it was withdrawn in January for trial in prediabetes patients. Maybe it will have a better result this time. Rick Phillipshttps://www.blogger.com/profile/06927227605885917738noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-24314696646977175252019-10-11T19:58:44.671-07:002019-10-11T19:58:44.671-07:00Thank you for all the post you've made. I'...Thank you for all the post you've made. I've been reading them but don't think I've commented before. Just wanted to say thank you for your work.Chrishttps://www.blogger.com/profile/16970754172470937050noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-23615844524491980442019-10-11T19:12:35.371-07:002019-10-11T19:12:35.371-07:00JDRF is a great organization doing great things fo...JDRF is a great organization doing great things for certain. Rick Phillipshttps://www.blogger.com/profile/06927227605885917738noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-14784284235904125842019-10-08T14:18:35.536-07:002019-10-08T14:18:35.536-07:00Bad newsBad newsBrunohttps://www.blogger.com/profile/17105149257424826726noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-30413533507706592252019-08-25T13:38:33.823-07:002019-08-25T13:38:33.823-07:00When could we expect a real non-invasive CGM?When could we expect a real non-invasive CGM?avianohttps://www.blogger.com/profile/00735153238335101407noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-36189521515149309742019-08-22T02:19:31.572-07:002019-08-22T02:19:31.572-07:00Thanks for sharing like this content. I really app...Thanks for sharing like this content. I really appreciate sharing your post. and also you can go through this site and read the interesting thing <a href="https://diabetes-care.medicaltechoutlook.com/vendors/top-diabetes-care-solution-providers-rid-16.html" rel="nofollow">Top Diabetes care Solution Providers</a>Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-73263541905565293382019-06-19T10:09:50.293-07:002019-06-19T10:09:50.293-07:00Thank you for writing about this. It's at leas...Thank you for writing about this. It's at least exciting to hear another method toward a cure. It seems like the encapsulation of beta cells is the leading "cure" effort right now.Chrishttps://www.blogger.com/profile/16970754172470937050noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-15588244657445490572019-05-06T11:14:48.877-07:002019-05-06T11:14:48.877-07:00Any cure for type 1 diabetes operating through som...Any cure for type 1 diabetes operating through some significant intervention in the immune system is bound to be risky, given how essential the normal functioning of the immune system is to health, and how any tinkering with it can heighten cancer risks. But that said, I wonder at the reasoning that the risks and harms of multiple sclerosis are sufficiently worse than those of type 1 diabetes to make the significant risks in treating the former but not the latter worthwhile. Type 1 diabetics face a high risk of death from hypoglycemia, deteriorate rapidly in terms of neurological and vascular health, suffer a significantly diminished life expectancy, and have a much reduced quality of life, while some multiple sclerosis patients can have a comparatively mild course of disease. I would rate both diseases about equal in terms of their misery and thus of their justification for drastic but potentially curative medical interventions.Oscarhttps://www.blogger.com/profile/02915452402029137589noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-72629739008886362542019-05-04T05:26:30.322-07:002019-05-04T05:26:30.322-07:00Dear Josh, could you please cover the story about ...Dear Josh, could you please cover the story about Stano lab's clinical trial for Gaba? BR TETKA MILEVAhttps://www.blogger.com/profile/18264777046922751395noreply@blogger.comtag:blogger.com,1999:blog-5472921328078253036.post-22928672772251240102019-04-18T06:28:11.296-07:002019-04-18T06:28:11.296-07:00It is interesting to speculate on what causes the ...It is interesting to speculate on what causes the rise and fall of new cases of type 1 diabetes over time. I once found a number of panicked reports of new cases of diabetes in young people in contrast to old and overweight people emerging in English medical books of the early nineteenth century. This made me suspect that the rise may have had something to do with Britain being the first country to become industrialized, especially since I could only find similar concerns about new cases in young people in German works in the 1840s, which matches Germany's relatively delayed industrialization compared to Britain. There was also a sudden rise in new type 1 cases in Poland in the 1970s, which some attributed to increased industrialization there as well.<br /><br />I think that type 1 diabetes is a 'gunpowder and match' disease, with the 'gunpowder' being an inherited predisposition of the immune system to respond excessively to some random threat, the 'match,' whether it is measles, chicken pox, or allergies, with the result that the overstimulated immune response goes on to attack the pancreatic beta cells. Thus any vaccination program will help a bit, but no program will ever be perfectly protective. The hygiene hypothesis may play a role here as well, with industrialization displacing the population away from germ-ridden farms and toward cleaner urban environments, where the immune system of children cannot learn to cope with a variety of challenges, and so lacks the strength and self-direction required to keep from producing auto-antibodies, hay fever, peanut allergies, and type 1 diabetes.Oscarhttps://www.blogger.com/profile/02915452402029137589noreply@blogger.com