Atrovastatin (much better known as Lipitor) has now finished it's second phase-II trial. The previous trial was unsuccessful, and this trial is unsuccessful, so I think that Lipitor is probably done as a potential cure for type-1 diabetes. You can read my previous blogging here:
http://cureresearch4type1diabetes.blogspot.com/search/label/Atorvastatin
This clinical trial started recruiting patients in July 2007, finished collecting data in July 2011, and finished completely in July 2013. It's now been 3 years since that date, and I cannot find a publication reporting on the results of this trial. In my experience trials with successful results are usually published within a year of completion, while those which are unsuccessful often languish for years, unpublished.
Clinical Trial Record: https://clinicaltrials.gov/ct2/show/NCT00529191
The previous Lipitor paper is here:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017554
Conclusion from this previous paper:
Atorvastatin treatment did not significantly preserve beta cell function although there may have been a slower decline of beta-cell function which merits further study.Discussion
The problem of researchers not publishing results from unsuccessful clinical trials has been getting some press recently. For example:
- https://www.washingtonpost.com/news/to-your-health/wp/2016/06/29/the-worlds-smartest-computer-will-help-treat-10000-veterans-with-cancer/
- https://www.statnews.com/2015/12/13/clinical-trials-investigation/
Joshua Levy
http://cureresearch4type1diabetes.blogspot.com
publicjoshualevy at gmail dot com
All the views expressed here are those of Joshua Levy, and nothing here is official JDRF, JDCA, or Tidepool news, views, policies or opinions. My daughter has type-1 diabetes and participates in clinical trials, which might be discussed here. My blog contains a more complete non-conflict of interest statement. Thanks to everyone who helps with the blog.
5 comments:
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Darn, I was hoping it would cure it? Shoot, well maybe spironolactone? I have my own 10 year trial of both and both have not cured me, but well maybe the 11th year?
I referred your blog to the TUDiabetes.org blog page for the week of August 1, 2016.
Rick, Joshua'ss blog is the one that talks about the research with complete impartiality and without false expectations.
My Son (22 months) was recently diagnosed with T1D and that has put me on a path looking for answers. I appreciate your coverage!!!
keep up the good work.
-Ed
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